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Titlebook: Chronic Myeloid Leukemia; Rüdiger Hehlmann Book 2021Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive licens

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发表于 2025-3-21 17:32:24 | 显示全部楼层 |阅读模式
书目名称Chronic Myeloid Leukemia
编辑Rüdiger Hehlmann
视频video
概述Presents state-of-the-art reviews of key issues relating to chronic myeloid leukemia.Covers a wide range of management topics.Discusses prognostic aspects and early response prediction.Examines the ch
丛书名称Hematologic Malignancies
图书封面Titlebook: Chronic Myeloid Leukemia;  Rüdiger Hehlmann Book 2021Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive licens
描述.This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health. Among the management topics addressed are the choices, advantages, and pitfalls of first-, second-, and third-line treatments; the European LeukemiaNet recommendations; management of adverse effects of tyrosine kinase inhibitors (TKI); management of CML blast crisis; management of pregnancy in the context of CML; the role of hematopoietic cell transplantation; the current experience with TKI discontinuation; and the value of interferon α in improving the outcome of TKI treatment. Various aspects of relevance to treatment outcome are discussed, including prognostic scores, molecular monitoring (principles and interlaboratory standardization), and response-related predictors of survival. Furthermore, updates are provided on the increasing prevalence of CML and its implications and on the changing cost of care for CML, taking into account the impact of availability of generic imatinib. .
出版日期Book 2021Latest edition
关键词Chronic myeloid leukaemia; BCR-ABL; Tyrosine kinase inhibitors; Philadelphia chromosome; Fertility; Hemat
版次2
doihttps://doi.org/10.1007/978-3-030-71913-5
isbn_softcover978-3-030-71915-9
isbn_ebook978-3-030-71913-5Series ISSN 2197-9766 Series E-ISSN 2197-9774
issn_series 2197-9766
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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发表于 2025-3-21 20:15:15 | 显示全部楼层
The Biology and Pathogenesis of Chronic Myeloid Leukaemia,he discovery of the Philadelphia (Ph) chromosome. This genomic abnormality is the result of a t(9;22) translocation, leading to the fusion oncogene, .. The resulting protein is capable of hijacking a vast repertoire of cellular functions that drive myeloid hyperplasia, characteristic of the initial,
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Epidemiology of Chronic Myeloid Leukaemia,r epidemiological research. CML registries with a more comprehensive reporting may also provide complementary data on treatment outcome to those obtained from clinical trials. Reports from several European CML registries consistently show a crude annual incidence of 0.7–1.3/100,000, median age at di
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Standardization of Molecular Monitoring for Chronic Myeloid Leukemia: 2021 Update,d to define time-related clinical milestones as well as eligibility for stopping treatment. To improve the comparability of molecular monitoring results between centers, an international scale (IS) for . measurement has been implemented by testing laboratories worldwide, either by the derivation of
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