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Titlebook: Chromothripsis; Methods and Protocol Franck Pellestor Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Massive

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书目名称Chromothripsis
副标题Methods and Protocol
编辑Franck Pellestor
视频videohttp://file.papertrans.cn/227/226365/226365.mp4
概述Includes cutting-edge methods and protocols for the study of chromothripsis.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the expert
丛书名称Methods in Molecular Biology
图书封面Titlebook: Chromothripsis; Methods and Protocol Franck Pellestor Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Massive
描述This detailed book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsis, the causal mechanisms of chromothripsis, the bioinformatics tools for chromothripsis analysis, and experimental systems recently developed for the .in vitro. investigation of chromothripsis. Written for the highly successful .Methods in Molecular Biology. series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. .Authoritative and practical, .Chromothripsis: Methods and Protocols. serves as a vital resource for cell biologists, molecular biologists, cytogeneticists, and geneticists investigating chromothripsis, but also for students and researchers new to the field of chromothripsis and genomic instability..
出版日期Book 2018
关键词Massive genomic alterations; DNA fragments; Complex derivative chromosomes; Cytogenetics; Bioinformatics
版次1
doihttps://doi.org/10.1007/978-1-4939-7780-2
isbn_softcover978-1-4939-9283-6
isbn_ebook978-1-4939-7780-2Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2018
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书目名称Chromothripsis影响因子(影响力)




书目名称Chromothripsis影响因子(影响力)学科排名




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Analysis of Chromothripsis by Combined FISH and Microarray Analysisermine the organization of abnormal genomes after chromothripsis and other types of complex genome rearrangement. DNA microarrays can identify the changes in copy number, but they do not give information on the organization of the abnormal chromosomes, balanced rearrangements, or abnormalities of th
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Identification of Chromothripsis in Biopsy Using SNP-Based Microarrays have shown that chromothripsis or chromoanasynthesis can result in complex genomic rearrangements by a single catastrophic event rather than several incremental steps. These two novel phenomena suggest an evolutionary modality for cancer cells to circumvent individual mutational events with one si
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Detection of Chromothripsis in Plantsly complex structural rearrangements. In plants, chromothripsis has been observed as a result of mitotic malfunction connected with the incomplete loss of haploid inducer chromosomes during uniparental genome elimination. Uniparental genome elimination, a process that results in haploid induction, i
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Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy this process frequently contain micronuclei, which can lead to genomic change and chromothripsis. In this chapter we describe how to induce checkpoint adaptation and detect it by time-lapse video and immunofluorescence microscopy and how to isolate cells undergoing checkpoint adaptation from a tota
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