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Titlebook: Chromosomes Today; Volume 11 A. T. Sumner,A. C. Chandley Book 1993 Springer Science+Business Media Dordrecht 1993 Chromosome.DNA.Interphase

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Deletions of chromosome 5 in malignant myeloid disordersar analysis has revealed that alterations in the function of the genes that are located at the breakpoints of the recurring structural rearrangements play an integral role in the process of malignant transformation. The transforming genes that are involved in chromosomal translocations fall into sev
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Chromosomal abnormalities in solid tumours the somatic mutation theory of carcinogenesis. Such chromosomal changes were in the past often dismissed as epiphenomena of no pathogenetic importance, but latterly the paradigm has changed, and they are now generally accepted as crucial events in multistage tumourigenesis.
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Characterization of the telomeric region of human chromosome 16pmponents can explain many of the properties of human telomeres; for example, replication of the terminal DNA, protection against exonucleolytic degradation, and the prevention of chromosome fusion (.).
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Compartmentalization of the cell nucleus: case of the nucleolusribosomal proteins, nucleolar proteins and ribonucleoproteins (RNPs) is required for the nucleolar function, including RNA polymerase I, DNA topoisomerases, transcription factors, processing enzymes, 5S rRNA and U3, U8, U13 and U14 small nucleolar RNAs (snoRNAs) (..).
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erned that scientists who worked on different aspects of chromosomes, or who studied them in different ways, should have the opportunity of "discussing the fundamental problems of chromosomes with one another". The fact that well over 300 scientists with a wide variety of interests came to Edinburgh
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Charakterisierungen und Konstruktionen such as cancer material and samples of testis. Probably the first recorded description of human chromosomes was by Arnold in 1879 using mitotic cancer cells (Table 1). Hansemann in 1891 and Flemming in 1898 attempted to count the number of chromosomes in serial sections, obtaining crude estimates of approximately 24.
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