Titlebook: Chromosomes Today; Volume 11 A. T. Sumner,A. C. Chandley Book 1993 Springer Science+Business Media Dordrecht 1993 Chromosome.DNA.Interphase

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ular biologists have now realized that they need to know about chromosomes, and indeed an important, if ill-defined discipline of ‘molecular cytogenetics‘ has grown up in recent years. We are pleased that in planning the Conference and this book, so much of the work presented is at the interface between cytog978-94-010-4660-2978-94-011-1510-0

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https://doi.org/10.1007/978-94-011-1510-0Chromosome; DNA; Interphase; Mutation; PCR; Telomere; Termination; Vivo; evolution; gene expression; genes; gen

oblique

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B-cell

Intermezzo: Zur Geschichte der Analysis the somatic mutation theory of carcinogenesis. Such chromosomal changes were in the past often dismissed as epiphenomena of no pathogenetic importance, but latterly the paradigm has changed, and they are now generally accepted as crucial events in multistage tumourigenesis.

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Charakterisierungen und Konstruktionenerest, but to inadequacy of the available material and technology. Mitoses could only be studied in histological sections of actively dividing tissues such as cancer material and samples of testis. Probably the first recorded description of human chromosomes was by Arnold in 1879 using mitotic cance

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Borelmengen und projektive Mengend that a specialized chromosomal substructure located at the surface of the centromere is responsible for these movements. This structure, the kinetochore, is typically described as a three-layered disk composed of two dense plates with a space between them (Rieder, 1982). The inner dense plate is c

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Intermezzo: Wohlordnungen und Ordinalzahlenomeric DNA, the conserved sequence at the extreme ends of chromosomes, comprises in mammals a variable length (2-20 kb in humans; 15-150 kb in mouse) of the simple sequence (TTAGGG). orientated 5’->3’ toward the chromosome end. It is likely that this repeat motif, together with associated protein co

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Intermezzo: Zur Geschichte der Analysischaracterized by different GC levels.In the human genome,which is representative of a number of mammalian genomes and, more broadly, of the genomes of warm-blooded vertebrates, the compositional spectrum of isochores ranges between 30% and 60% GC, and five families of isochores have been identified,