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Titlebook: Chromosome Analysis Protocols; John R. Gosden Book 1994 Humana Press 1994

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https://doi.org/10.1007/978-3-662-09709-0 mapping is the method of first choice. Accurate chromosomal localization is usually a multistep process starting first with assignment to one of the 23 chromosomes, and progressing to increasingly refined subregional localization. Somatic cell hybrids and . hybridization (..) have been the techniques most often used.
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Redirections in the Study of Expert Labour., ref. .). In time, it became possible to map unique sequences (e.g., ref. .), but this was a tedious procedure involving the analysis of grain distribution over large numbers of metaphase spreads, in order to distinguish specific hybridization signal from background grains.
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