Titlebook: Chromosomal Alterations; Origin and Significa Günter Obe,Adayapalam T. Natarajan Book 1994 Springer-Verlag Berlin Heidelberg 1994 Chromosom

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Investigations of Aberration Origins Using BrdUrd,tion of the newly synthesised strands is reflected at the chromosome level. Thus, after one S-phase all replicated chromatin has Br in one strand of the DNA (unifilar substitution, TB) but after two S-phases, sister-chromatids differ, one containing unifilar, TB chromatin, the other bifilar substitu

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Use of Antitopoisomerase Drugs to Study the Mechanisms of Induction of Chromosomal Damage,ents which induce specific damage to DNA that can be followed in its evolution to produce chromosomal aberrations. Another approach consists of using agents that affect different cellular functions (i.e. DNA synthesis and repair) which are required to overcome the damage induced at the DNA level. Th

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Search for Perturbations induced by X-irradiation in the G2 Phase of Human Lymphocytes,delay induced by low doses of X-irradiation has lead to extensive investigations during the last decade (e.g. Bender 1989; Doida and Okada 1969; Hsu et al. 1962; Mindek 1986; Natarajan and Obe 1978; Obe at al. 1982; Revell 1959; Rowley 1992; Savage and Papworth 1973; Schneidermann et al. 1977; Scott

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A Comparison of Radiation-Induced Aberrations in Human Cells Involving Early and Late Replicating Xg . chromosome arms. He found these frequencies appreciably higher in the proximal compared to the distal one-third of the arms, and concluded that “...chromosome break or exchange points do not occur at random in the chromosome” (Sax 1938). At the same time he also noted that “....the greatest freq

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Synergism and Adaptive Response in the Interaction of Low Dose Irradiation with Subsequent Mutagenis and dose rates, however, still remain ambiguous (Pohl-Rüling 1990; Sagan 1987). The study of interaction of low dose irradiation with subsequent mutagenic treatment could be a way of evaluating the effects of low doses of irradiation. This type of research has linked to a general biological phenom

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