Titlebook: Chromosomal Aberrations; Basic and Applied As Günter Obe,A. T. Natarajan Book 1990 Springer-Verlag Berlin Heidelberg 1990 Chromosomen.DNA.D

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The Use of Restriction Endonucleases to Study the Mechanisms of Chromosome Damage,ethods for introducing restriction enzymes into cells, and the effects of restriction enzymes on the induction of DNA double-strand breaks, chromosome aberrations, and sister chromatid exchange (SCE).

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Heterogeneity of DNA Repair in Relation to Chromatin Structure, Also, in a number of other cases the removal of pyrimidine dimers from the genome overall turned out to be an invalid parameter to predict UV-induced cytotoxicity. Cockayne’s syndrome (CS) is a human disorder characterized at the cellular level by an increased sensitivity to the killing effects of

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The Poly-ADP-Ribosylation System of Higher Eukaryotes: How Can It Do What?, us a clue to the biological role of this posttranslational protein modification in chromatin. However, the phenotype of a genetically engineered cell under- or overexpressing components of the poly-ADP-ribosylation system may be difficult to interpret, since these cells, if viable at all, may exhib

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Induction of Chromosomal Aberrations by the Restriction Endonuclease AluI in Chinese Hamster Ovary ). Analyses of Bryant and Christie (1989) have shown that the uptake of REs using the “pellet technique” is dependent on the shipping buffer in which the REs are suspended. The authors assume that “this may result from a combination of hypertonic shock and the detergent present in the shipping buffe

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Possible Causes of Variability of the Adaptive Response in Human Lymphocytes,nted by a mutagenic agent one of the most interesting responses is the adaptive response (AR; Samson and Cairns 1977). The mechanisms underlying the AR are reasonably well known in prokaryotes in which they were discovered (Sekiguchi and Nakabeppu 1987; Rebeck et al. 1988). In plant (Rieger et al. 1

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Radio-Adaptive Response: A Novel Chromosomal Response in Chinese Hamster Cells in Vitro, et al. 1982). Interestingly, the adaptive response has been recently found to occur in human lymphocytes exposed to low doses of ionizing radiation (Olivieri et al. 1984; Shadley and Wolff, 1987; Sankaranarayanan et al. 1989). A pretreatment with “conditioning” or “adapting” low doses of either tri

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