Titlebook: Chromosomal Aberrations; Basic and Applied As Günter Obe,A. T. Natarajan Book 1990 Springer-Verlag Berlin Heidelberg 1990 Chromosomen.DNA.D

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Patterns of Chromosome Variation in Neoplasia,day the basic question in cancer cytogenetics. It is now established beyond doubt that most neoplasms, benign and malignant, in both experimental animals and man, have karyotypic changes detectable with existing cytogenetic techniques. The unresolved question is: Are these abnormalities the cause or the consequence of the malignant state?

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William N. Valentine,Donald E. PagliaBs, induce chromosomal aberrations in a pattern similar to that induced by ionizing radiations, i.e., chromosome type of aberrations in G1 and chromatid type of aberrations following G2 treatment (Natarajan and Obe 1984, Obe and Winkel 1985).

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