Titlebook: Cholinesterases and Anticholinesterase Agents; George B. Koelle (Professor and Chairman) Book 1963 Springer-Verlag Berlin Heidelberg 1963

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The Active Site of Acetylcholinesterase and Related Esterases and its Reactivity towards Substrates any alternative aspects outside the scope of the present paper the reader is referred to excellent articles available in the literature including those by . (1948 and 1951 c), . (1959), . and . (1951), . (1951), . (1958) and chapters 4, 8, and 9 of the present handbook

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Identification of Acetylcholine and Related Esters of Biological Originveral facts which warn us against attributing a too exclusive role to this compound. First, by analogy with other transmitters (e.g., the catecholamines) the transmitter role is likely to be subserved by a group of related substances rather than by a single compound. Second, ACh occurs in non-nervou

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Formation, Storage, and Liberation of Acetylcholineowing its release be replaced rapidly enough for transmission to occur repetitively in response to successive nerve impulses. The question of how the ester is replaced at the release points of the synapse in available form is one which as yet can be answered only in the most general way. In tissue s

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Classification and Comparative Enzymology of the Cholinesterases and Methods for their Determinationhe last 20 years on the specificity of these enzymes, their role in physiological systems, and the pharmacological importance of cholinesterase inhibitors. Everybody taking part in this discussion on the biochemical level will probably agree with the following; There are enzymes present in the anima

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Cytological Distributions and Physiological Functions of Cholinesteraseslular and subcellular levels, as illustrated by most of the chapters in the present volume. The magnitudes and sequences of the electrical signs associated with neuronal activity could be defined accurately only after the development of reliable single unit and intracellular recording techniques. At