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Titlebook: Cholinesterases and Anticholinesterase Agents; George B. Koelle (Professor and Chairman) Book 1963 Springer-Verlag Berlin Heidelberg 1963

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楼主: 猛烈抨击
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Conference proceedings 1987Latest editionedicinal uses. By far the most important use of these agents at the present time, from the standpoint of both the quantities involved and benefits derived, is for the eradication of destructive insects. High toxicity to insects is thus an essential requirement for anti-ChE agents.
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Metabolism of Organophosphorus Anticholinesterase Agentsal industries . and . (1953) have pointed out that any extensively toxic substance is to be suspected . of being an inhibitor of some vitally important enzyme system, and the physiological process characteristic of a number of organophosphorus compounds was found to be the inhibition of cholinesterases (ChE’s).
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Toxicological Evaluation of the Anticholinesterase Agentsedicinal uses. By far the most important use of these agents at the present time, from the standpoint of both the quantities involved and benefits derived, is for the eradication of destructive insects. High toxicity to insects is thus an essential requirement for anti-ChE agents.
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https://doi.org/10.1007/978-3-322-90876-6e; non-choline esters are also hydrolyzed, but at a lower rate. The specificity of cholinesterases therefore is not absolute, and “true” cholinesterases do not exist as far as the specificity is concerned.
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https://doi.org/10.1007/978-3-642-48210-6lates. However, the chemistry of the structures and specific reactions involved in nervous function can for the most part be described only at the tissue or relatively gross cellular level, and the cytological details as to where the various reactions occur are largely conjectural.
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https://doi.org/10.1007/978-3-642-48031-7. The only complete review of the pharmacology of anti-ChE agents presently available is the excellent one by . (1959) which, however, does not include cholinesterase (ChE) inhibitors other than organophosphorus compounds.
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Cytological Distributions and Physiological Functions of Cholinesteraseslates. However, the chemistry of the structures and specific reactions involved in nervous function can for the most part be described only at the tissue or relatively gross cellular level, and the cytological details as to where the various reactions occur are largely conjectural.
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