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Titlebook: Cholesterol Transport Systems and Their Relation to Atherosclerosis; Armin Steinmetz,Hans Kaffarnik,Jürgen Schneider Conference proceeding

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书目名称Cholesterol Transport Systems and Their Relation to Atherosclerosis
编辑Armin Steinmetz,Hans Kaffarnik,Jürgen Schneider
视频videohttp://file.papertrans.cn/227/226161/226161.mp4
丛书名称Recent Developments in Lipid and Lipoprotein Research
图书封面Titlebook: Cholesterol Transport Systems and Their Relation to Atherosclerosis;  Armin Steinmetz,Hans Kaffarnik,Jürgen Schneider Conference proceeding
描述A number of clinical and epidemiological studies have shown that disorders of lipoprotein metabolism constitute one of the most important risk factors for the development of atherosclerosis and coronary heart disease. This volume examines the state of the art of lipoprotein subclass metabolism and its relation to these diseases. The authors also report on new developments concerning the role of lipoprotein recptors, macrophages and apolipoprotein E polymorphism in cholesterol homeostasis. The combination of general outline form and very specific aspects of cholesterol transport will interest those in other disciplines following developments in the field, as well as those directly involved in lipoprotein research.
出版日期Conference proceedings 1989
关键词Lipoprotein; atherosclerosis; heart; high-density lipoprotein (HDL); homeostasis; metabolism; protein; meta
版次1
doihttps://doi.org/10.1007/978-3-642-83665-7
isbn_softcover978-3-540-50548-8
isbn_ebook978-3-642-83665-7Series ISSN 1431-7567
issn_series 1431-7567
copyrightSpringer-Verlag Berlin Heidelberg 1989
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https://doi.org/10.1007/978-3-642-75092-2 experimentally to manipulate the proportion of molecules degraded or recycled [5, 6]. With the fundamental properties of receptor-mediated endocytosis in mind, we examined the HDL pathway using as the ligands HDL and an apo A-I containing hybrid protein constructed using recombinant DNA techniques.
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An Apo A-I Protein A Hybrid Used for the Study of HDL Receptor Binding and Endocytosis experimentally to manipulate the proportion of molecules degraded or recycled [5, 6]. With the fundamental properties of receptor-mediated endocytosis in mind, we examined the HDL pathway using as the ligands HDL and an apo A-I containing hybrid protein constructed using recombinant DNA techniques.
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Regulation of Macrophage Cholesterol HomeostasisThe occurence of receptor defects [1] or structural defects of apolipoproteins [2] prevent a normal lipoprotein-receptor interaction. The abnormal lipoprotein particles thus formed are enriched with cholesteryl esters and are catabolized via a separate, so-called scavenger pathway in the macrophage system.
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