Titlebook: Cholesterol Modulation of Protein Function; Sterol Specificity a Avia Rosenhouse-Dantsker,Anna N. Bukiya Book 2019 The Editor(s) (if applic

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Cholesterol-Dependent Gating Effects on Ion Channelslipids, depending on whether there are phosphate groups in the headgroup regions. Cholesterol (CHOL) is one type of nonphospholipids, and one of the most abundant lipid molecules in humans. Its content in plasma membranes and intracellular membranes varies and is tightly regulated. Voltage-gated ion

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Rechnerstrukturen und Betriebsprogrammierungdentical physiochemical properties as .cholesterol. Hence, if the biological effects of cholesterol result solely due to membrane effects, it is expected that there will be no difference between .cholesterol and .cholesterol. However, when direct binding with chiral proteins and lipids is involved,

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https://doi.org/10.1007/3-540-06815-5from representative GPCRs. While evidence for both the proposed mechanisms exists, there appears to be no clear-cut distinction between these two mechanisms, and a combination of these mechanisms cannot be ruled out in many cases. We conclude that classifying the mechanism underlying cholesterol sen

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Bernd Bundschuh,Peter Sokolowskyen direct and indirect effects, it does not account for the promiscuity of cholesterol binding sites, which can potentially accommodate cholesterol . its chiral isomers. In this chapter, we use docking analyses to explore the idea that the specificity of cholesterol’s effect on Kir channels is depen

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