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Titlebook: Cholesterol Modulation of Protein Function; Sterol Specificity a Avia Rosenhouse-Dantsker,Anna N. Bukiya Book 2019 The Editor(s) (if applic

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书目名称Cholesterol Modulation of Protein Function
副标题Sterol Specificity a
编辑Avia Rosenhouse-Dantsker,Anna N. Bukiya
视频videohttp://file.papertrans.cn/227/226160/226160.mp4
概述Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function.Contributors are well-known experts in their fields and provide international perspective.R
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Cholesterol Modulation of Protein Function; Sterol Specificity a Avia Rosenhouse-Dantsker,Anna N. Bukiya Book 2019 The Editor(s) (if applic
描述.In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. .This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions.  In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. . The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in t
出版日期Book 2019
关键词cholesterol modulation; protein function; membrane cholesterol; lipid sensors; cholesterol distribution;
版次1
doihttps://doi.org/10.1007/978-3-030-04278-3
isbn_ebook978-3-030-04278-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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Cholesterol Modulation of Protein Function978-3-030-04278-3Series ISSN 0065-2598 Series E-ISSN 2214-8019
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Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/c/image/226160.jpg
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Rechnerstrukturen und Betriebsprogrammierung cellular membranes and regulates membrane fluidity and permeability. Cholesterol is also essential for normal functioning of key proteins including ion-channels, G protein-coupled receptors (GPCRs), membrane bound steroid receptors, and receptor kinases. It is thought that cholesterol exerts its ac
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https://doi.org/10.1007/3-540-06815-5s mediate a wide range of physiological processes and have emerged as major targets for the development of novel drug candidates in all clinical areas. Since GPCRs are integral membrane proteins, regulation of their organization, dynamics, and function by membrane lipids, in particular membrane chol
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Nichtsequentielle Rechnerarchitekturen,py. The approach allows one to quantify the average membrane structure, fluctuations, and elastic deformation upon cholesterol interaction. Emphasis is placed on understanding the membrane structural deformation and emergent fluctuations at an atomistic level. Lineshape measurements using solid-stat
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