Titlebook: Chirurgisches Forum 2001 für experimentelle und klinische Forschung; 118. Kongreß der Deu K. Schönleben (Präsident des 118. Kongresses der

Angiogenesis

Die Rolle der Apoptose-regulierenden Proteine Bcl-xL und Bax in der durch Gemcitabin induzierten Cytcarcinoma. We show that 5/6 pancreatic carcinoma cell lines undergo DNA fragmentation and morphological changes typical for apoptosis following a 48-h exposure to gemcitabine (Gemzar® 0,1 –100 μg/ml). Apoptotic DNA fragmentation occurred in a dose-dependent manner and correlated with the expression

小平面

cavity

Rapamycin inhibiert das Tumorwachstum und die Tumormetastasierung über Antiangiogenese and recurrence are ominous risk factors for these immunocompromised patients. In the present study we show that the new immunosuppressive drug rapamycin may have a unique ability to reduce the risk of cancer development, while simultaneously providing effective immunosuppression. Experimentally, ra

fiction

Anti-angiogene Gentherapie mittels eines dominant negativen VEGF-R2 kodierendem Retrovirusese the most important one in this process. In the present study we analyzed the role of VEGF and its receptors in growth of pancreatic cancer (PaCa). We analyzed expression of VEGF and both receptors -RI and -RII in human specimens and further elucidated the effect of therapeutic inhibition of VEGF s

慢慢流出

逃避责任

Expression der Multi-Drug-Resistance-Gene mdr1 und mrp in kolorektalen Karzinomensa of the gastrointestinal tract. They mediate multidrug resistance against cytostatic drugs in colorectal carcinoma. Since cytostatic therapy in colorectal carcinoma with 5-FU is successful in only 23%, it will be of interest to identify .- and .-negative tumors to use more efficient drugs. . In sp

Champion

Eine neue T-Zellpopulation in der anti-tumoralen Immunantwort: CD8+ NKT-Zellen begünstigen Tumorabstor response. Their function, regulation and relationship to other cells in the immune system are not fully understood. We investigated the role of NKT cells in a tumor mouse model. . This work was based on a established tumor model with EL4 thymoma cells that were transfected with costimulatory mole

有常识

Focal Adhesion Kinase (FAK) reguliert Zelladhäsion von HT-29 Kolon-Karzinomzellen an extrazelluläreresion kinase (FAK) is an important part of integrin-related focal adhesion plaques and adhesion-mediated signal transduction. Under laminar flow conditions shear forces can modify various cellular functions, including phosphorylation events and cytoskeletal alterations involved in signal transductio

nocturnal

Effekt von Paclitaxel verpackt in kationische Liposomen auf Wachstum und Metastasierung solider Tumory to tumor vasculature and tumor cells. The aim of our study was to evaluate the antitumoral efficacy of paclitaxel encapsulated in cationic liposomes in comparison to paclitaxel dissolved in alcoholic cremophor EL (Taxol) in vivo. . Experiments were carried out in male Syrian golden hamsters (40 –

我要沮丧