Titlebook: Chiral Liquid Chromatography; W. J. Lough Book 1989 Chapman & Hall 1989 Enantiomer.chromatography.information.optimization.pharmaceutical.

implore

Consideration of other techniquesThe first step to take in developing an assay in chiral liquid chromatography is self-evident; the question must be asked, ‘Is LC the best technique to use?’ This is especially so since there is a surprising variety of techniques available for the determination of enantiomers, and the number of options is ever-increasing.

Vulnerary

OptimizationAs suggested in the previous chapter, the process of method development does not end when enantiomeric resolution is obtained. In almost every case, a further fine-tuning of experimental variables will be necessary, or at least advisable.

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The Challenge for Public Health,ution of enantiomers from a racemate goes to Louis Pasteur who, in 1848, separated manually the non-identical crystals of the enantiomers of sodium ammonium tartrate (Pasteur, 1848). In 1874, Le Bel and Van’t Hoff independently proposed the ‘asymmetric carbon atom’ to account for the chirality of or

Introvert

Overview of formalism and systems,es. Derivatization of chiral substances is carried out with both chiral and achiral reagents. The latter may serve to block functional groups which may cause excessive band broadening on chiral columns (e.g, amines), or to introduce groups which interact favourably with the chiral stationary phase (

Petechiae

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The revision in terminological systems,ltipleinteraction bonded phases. This class of CSP has arisen during the past ten years or so, nurtured by an eminently sensible idea: that the greater the number of specific, discrete, simultaneous interactions between chiral solute molecules and a chiral locus on the stationary phase, then the gre

amplitude

Terminological reason maintenance,al system including the complexation (or binding) of xenobiotic materials. As proteins are chiral polymers, it is not surprising that the binding of small enantiomeric molecules is often stereospecific. This is especially true for the serum proteins α.-acid glycoprotein (AGP) and albumin (SA).

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