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Titlebook: Chiral Liquid Chromatography; W. J. Lough Book 1989 Chapman & Hall 1989 Enantiomer.chromatography.information.optimization.pharmaceutical.

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发表于 2025-3-21 16:59:00 | 显示全部楼层 |阅读模式
书目名称Chiral Liquid Chromatography
编辑W. J. Lough
视频video
图书封面Titlebook: Chiral Liquid Chromatography;  W. J. Lough Book 1989 Chapman & Hall 1989 Enantiomer.chromatography.information.optimization.pharmaceutical.
描述While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, expe
出版日期Book 1989
关键词Enantiomer; chromatography; information; optimization; pharmaceutical; pharmaceutical industry; pharmaceut
版次1
doihttps://doi.org/10.1007/978-94-009-0861-1
isbn_softcover978-94-010-6875-8
isbn_ebook978-94-009-0861-1
copyrightChapman & Hall 1989
The information of publication is updating

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Chiral liquid chromatography: past and presentution of enantiomers from a racemate goes to Louis Pasteur who, in 1848, separated manually the non-identical crystals of the enantiomers of sodium ammonium tartrate (Pasteur, 1848). In 1874, Le Bel and Van’t Hoff independently proposed the ‘asymmetric carbon atom’ to account for the chirality of or
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Chiral derivatizationes. Derivatization of chiral substances is carried out with both chiral and achiral reagents. The latter may serve to block functional groups which may cause excessive band broadening on chiral columns (e.g, amines), or to introduce groups which interact favourably with the chiral stationary phase (
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Chiral ligand exchange chromatographynd ligand introduced to the chromatographic system. Chromatography thus performed is highly selective for the differentiation of chelatable solutes. Stereoselective resolution of isomeric ligands can be achieved if the system ligand is optically active and forms a chiral complex in the presence of a
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Immobilized proteins as HPLC chiral stationary phasesal system including the complexation (or binding) of xenobiotic materials. As proteins are chiral polymers, it is not surprising that the binding of small enantiomeric molecules is often stereospecific. This is especially true for the serum proteins α.-acid glycoprotein (AGP) and albumin (SA).
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Binding to cellulose derivativestive polymers. Like the interaction between an enzyme and its substrate, the polymer can lock on to the different stereochemistries of each enantiomer and provide chiral recognition. Proteins, oligosaccharides and celluloses have had the greatest degree of success, although usually bonded on to sili
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Binding to synthetic polymerso mimic and improve upon them. This expected development has taken place, and synthetic polymer chiral stationary phases (CSPs) are amongst the most recent to be made commercially available. As for natural polymers these synthetic polymers must first be immobilized on silica in some way to be of any
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