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Titlebook: Chemotherapy of Fungal Diseases; John F. Ryley Book 1990 Springer-Verlag Berlin Heidelberg 1990 Chemotherapeutikum.Mykose.Pilzkrankheit.ch

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书目名称Chemotherapy of Fungal Diseases
编辑John F. Ryley
视频video
丛书名称Handbook of Experimental Pharmacology
图书封面Titlebook: Chemotherapy of Fungal Diseases;  John F. Ryley Book 1990 Springer-Verlag Berlin Heidelberg 1990 Chemotherapeutikum.Mykose.Pilzkrankheit.ch
描述Fungal diseases have been with us from antiquity; interest in the chemo­ therapy of fungal disease has exploded in the past decade. To plan and pro­ duce a book on the topic of antifungal chemotherapy has come as a personal challenge - and something of an eye-opener - towards the end of my re­ search career. A landmark publication which still merits reading is Antifungal Chemotherapy (John Wiley & Sons, Chichester, UK), edited by David Speller, which appeared in 1980. However, the fact that ketoconazole, the first of the modern, orally active, wide-spectrum antifungals, attracted no more than two sentences in it indicates just how far we have come in the 1980s. A steady stream of original papers and a number of conference proceedings have chronicled this progress in drug research; outstanding among the latter are the proceedings of an international telesymposium, entitled Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents, edited by Robert Fromtling (J.R. Prous, Barcelona, 1987) and volume 544 of the Annals of the New York Academy of Sciences, entitled Antifungal Drugs, edited by Vassil St. Georgiev, and containing papers and posters presented at a most
出版日期Book 1990
关键词Chemotherapeutikum; Mykose; Pilzkrankheit; chemotherapy; drug; drug discovery; screening
版次1
doihttps://doi.org/10.1007/978-3-642-75458-6
isbn_softcover978-3-642-75460-9
isbn_ebook978-3-642-75458-6Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1990
The information of publication is updating

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Introduction hovers over his retort planning what to brew up next. His thinking may be directed by analogy with known active structures or by fashionable biochemical pathways, but beyond this the medicinal chemist needs a vision and a feel for the target.
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Drug Discovery: Nature’s Approach without causing damage to mammalian cells. Herein we will cover some of the current research in the discovery and evaluation of new antifungal agents from natural sources, and also the current methodology used in their biological evaluation as potential clinical candidates. In addition, a survey of
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Screening and Evaluation In Vivocompounds in the body and the different sites of fungal location, some indication of the . spectrum of activity is desirable; e.g. although . is basically susceptible to amphotericin B and systemic infections do show a response to treatment, vaginal ones do not. Other compounds will be basically nar
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Introductionnd regulatory procedures burgeoned in the hope of avoiding a similar situation in the future. Sally Eardley, a colleague from ICI, has written a delightful chapter (11) chronicling regulatory developments over the past 3500 years. Although she has had no experience with antifungal drugs, I find her
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Formulationmonstrated how tricks of formulation can reduce potential toxicity without affecting antifungal activity and thus increase the utility of the compound. It is in the area of topical formulation that most scope exists for presenting the compound in a way in which it will reach the fungus, persist unti
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