Titlebook: Chemosensitivity Testing in Oncology; Uwe Reinhold,Wolfgang Tilgen Conference proceedings 2003 Springer-Verlag Berlin Heidelberg 2003 brea

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Development of a New In Vitro Chemosensitivity Test Using Collagen Gel Droplet Embedded Culture and er drugs can be selected for each patient using the screening methods. In such a background, we developed a new anticancer-drug sensitivity testing method that overcame several defects in the existing method, which is the collagen gel droplet embedded culture drug sensitivity test (CD-DST) and satis

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In Vitro Chemosensitivity Testing of Hematological Cancer Patients: Detection of Ornithine Decarboxyer research and treatment. Early attempts to develop individualized chemotherapy were based on clonogenic assays. These attempts failed because of low plating efficiencies. Nonclonogenic assays, such as the MMT test or ATP determinations, are based on metabolic activities and do not reflect the abil

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The Chemosensitivity Profile of Retinoblastomaed in retinoblastoma as adjuvant therapy to prevent the growth of metastases and to treat metastatic disease once this has become clinically apparent. Current regimens are based on empirical drug combinations, and few clinical trials have been conducted because of the rarity of this tumour. Chemosen

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Human Melanoma: Drug Resistancece of melanoma cells to systemic treatment with antineoplastic agents. The reasons for the chemoresistant phenotype are currently unknown. The relevance of well-analyzed drug resistance mechanisms in melanoma such as intracellular and extracellular transport, drug resistance by induction of certain

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Assay-Assisted Treatment Selection for Women with Breast or Ovarian Cancereir lives. The use of these agents is based on demonstrated benefit in large randomized clinical trials, and the clinical activity of these chemotherapy regimens is initially high, with 60%–70% of patients responding. Unfortunately, their benefit in the second-line setting is often limited, with les

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cyanosis

Treosulfan in the Treatment of Metastatic Melanoma: From Chemosensitivity Testing to Clinical Trialsotential new drugs in this disease. To examine the effects of the bifunctional alkylating cytostatic treosulfan, an in vitro microplate ATP bioluminescence assay (ATP-TCA) was used. Five highly chemoresistant melanoma cell lines and melanoma cells freshly isolated from metastases surgically resected