| 书目名称 | Chemosensitivity Testing in Oncology |
| 编辑 | Uwe Reinhold,Wolfgang Tilgen |
| 视频video | |
| 丛书名称 | Recent Results in Cancer Research |
| 图书封面 |  |
| 描述 | Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - |
| 出版日期 | Conference proceedings 2003 |
| 关键词 | breast cancer; cancer; cell; chemotherapy; clinical trial; drug; drug development; drug resistance; leukemia |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-19022-3 |
| isbn_softcover | 978-3-642-62412-4 |
| isbn_ebook | 978-3-642-19022-3Series ISSN 0080-0015 Series E-ISSN 2197-6767 |
| issn_series | 0080-0015 |
| copyright | Springer-Verlag Berlin Heidelberg 2003 |
发表于 2025-3-21 18:47:20
