Titlebook: Chemical Protein Synthesis; Xuechen Li Book 2022 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Scie

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Preparation of Site-Specific Succinylated Histone Mimics to Investigate Its Impact on Nucleosome Dycture. Lysine succinylation is a recently discovered PTM that plays critical roles in metabolism, epigenetic signaling, and is correlated with several diseases. One significant challenge in studying the effects of this modification on nucleosome dynamics is to obtain site-specifically modified histo

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Sulfonium-Tethered Peptide,a series of methods including CIH, TD coupling, Met-Met, and Cys-Met bis-alkylation strategy to switch peptides’ secondary structure and enhance their stability and cellular uptake. Here we focus on the peptide macrocyclization method of Met-Met and Cys-Met bis-alkylation strategy to generate more s

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PAL-Mediated Ligation for Protein and Cell-Surface Modification,ficiency and mild aqueous reaction conditions, these ligases have emerged as powerful biotechnological tools for protein manipulation in recent years. PALs are enzymes of the asparaginyl endopeptidase (AEP) superfamily but have predominant transpeptidase activity as opposed to typical AEPs which are

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Development of a Glycoform Library-based Strategy to Decipher the Role of Protein Glycosylation,forms). The study of glycosylation is significantly impeded because of the heterogeneous nature of glycoproteins. To overcome this challenge, we developed and optimized a glycoform library-based strategy to investigate the role of protein glycosylation. In this strategy, chemical synthesis was used

Legion

A Selenium-based Cysteine Surrogate for Protein Chemical Synthesis,medium. SetCys does not interfere with the native chemical ligation reaction under mild reducing conditions, that is in the absence of tris(2-carboxyethyl)phosphine (TCEP). In contrast, subjecting SetCys to TCEP results in the spontaneous loss of its .-selenoethyl appendage and thus to its conversio

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