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Titlebook: Chemical Mutagens; Principles and Metho Frederick J. Serres Book 1984 Plenum Press, New York 1984 Chromosom.DNA.biology.cell lines.genotype

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Induction of Bacteriophage Lambda by DNA-Interacting Chemicals,iophage gene expression from the repressed to the active state (induction) is one of the manifestations of the “SOS response,” among such others as mutagenesis, increased DNA repair activity, filamentation, and suppression of respiration..The SOS functions have in common the property of being contro
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The Granuloma Pouch Assay,expensive screening tests utilizing prokaryotic and/or eukaryotic cells. These phase I or tier I tests should have a low potential to produce false negative results. This is often achieved by the acceptance of a certain number of false positive results. Therefore chemicals that show positive, contra
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The Use of Multiply Marked , K12 Strains in the Host-Mediated Assay,e has been a recrudescence of testing of environmental chemicals for genotoxicity. Experiments performed in particular with the./mammalian microsome test,. in which the ability of chemicals to cause reversion in auxotrophic. strains is determined on selective agar medium under the influence of vario
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Mutation in Somatic Cells as Determined by Electrophoretic Analysis of Mutagen-Exposed Chinese Hamsone charge for those of another, electrophoresis has been a useful procedure in identifying genetically variant forms of proteins. The procedure was made available to the study of a wide range of proteins (enzymes) as a result of the application of histochemical staining to gels after electrophoresi
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