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Titlebook: Chemical Mutagens; Principles and Metho Frederick J. Serres Book 1984 Plenum Press, New York 1984 Chromosom.DNA.biology.cell lines.genotype

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书目名称Chemical Mutagens
副标题Principles and Metho
编辑Frederick J. Serres
视频video
图书封面Titlebook: Chemical Mutagens; Principles and Metho Frederick J. Serres Book 1984 Plenum Press, New York 1984 Chromosom.DNA.biology.cell lines.genotype
描述Volume 9 of Chemical Mutagens consists mainly of chapters discussing the development and validation of short-term assays to detect the mutagenic effects of environmental chemicals. These chapters include an assay with the grasshopper neuroblast, a comparison of mutagenic responses of human lung-derived and skin-derived diploid fibroblasts, a forward-mutation assay in Salmonella, a multigene sporulation test in Bacillus subtilis, a specific locus assay in mouse lymphoma cells, a study of the induction of bacteriophage lambda, and the granuloma pouch assay. In addition, there are two chapters on the identification of mutagens in cooked food and in human feces. Frederick 1. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 The Grasshopper Neuroblast Short-Term Assay for Evaluating the Effects of Environmental Chemicals on Chromosomes and Cell Kinetics 1 Mary Esther Gaulden, Jan C. Liang, and Martha J. Ferguson 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Embryo Supply. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 1. Species. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
出版日期Book 1984
关键词Chromosom; DNA; biology; cell lines; genotypes; mercury; toxicity; ecotoxicology
版次1
doihttps://doi.org/10.1007/978-1-4613-2147-7
isbn_softcover978-1-4612-9267-8
isbn_ebook978-1-4613-2147-7
copyrightPlenum Press, New York 1984
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Baiming Zhao,Nan Xie,Junxiao Ge,Weimin Chen an important support of the somatic mutation theory of the etiology of cancer. The recent demonstration that a single point mutation, a GC to TA transversion, leads to the activation of a human oncogene. is in agreement with this suggestion.
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Junxi Fu,Kunpeng Zhao,Jiangxue Chenoth prokaryotic and eukaryotic cells should be used in preliminary screening to detect potential mutagens.. Bacterial tests are efficient and economical methods of detecting specific locus mutations. Moreover, well-developed methods of genetic manipulation make it easier to study mechanisms in bacte
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Huikui Zhou,Mudan Gu,C. Puttamadappahemicals. In a typical test application, thymidine kinase- competent (TK.) 3.7.2C L5178Y cells are exposed to five or more different concentrations of the test substance for 1–4 hr, maintained 48–72 hr in growth medium, then cloned in soft-agar medium in a single-step selection process to detect mut
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Mingming Lyu,Maomao Liu,Zhaoqing Luexpensive screening tests utilizing prokaryotic and/or eukaryotic cells. These phase I or tier I tests should have a low potential to produce false negative results. This is often achieved by the acceptance of a certain number of false positive results. Therefore chemicals that show positive, contra
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A CRF-Based Method for DDoS Attack Detectione has been a recrudescence of testing of environmental chemicals for genotoxicity. Experiments performed in particular with the./mammalian microsome test,. in which the ability of chemicals to cause reversion in auxotrophic. strains is determined on selective agar medium under the influence of vario
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Factors Affecting Development of Blockchain,tern Europe women get more breast cancer and men get more lung cancer than colon cancer). In the U. S. over 100,000 cases of colon cancer can be expected each year in the 1980s, and about 45% of the cases will be fatal.. The incidence of the disease in the U. S. appears to have stabilized since the
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