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Titlebook: Chemical Biology; Methods and Protocol Jonathan E. Hempel,Charles H. Williams,Charles C. Book 2015 Springer Science+Business Media New Yor

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Styles, Templets, and Custom Controls, to clinical translation. Here, we present a chemical biology approach that uses perturbation with small molecules of known mechanism to reveal mechanistic and therapeutic consequences of human disease alleles. To maximize human applicability, we perform chemical screening on multiple cell lines iso
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Styles, Templates, and Custom Controls,tion of small-molecule compounds spotted and immobilized on a glass slide surface, providing a multiplex platform to identify small-molecule compounds binding to a protein of interest in high-throughput screening. Several research groups have developed a variety of methods for the immobilization of
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Dependency Properties and Routed Events,and humans share many structurally and functionally related gene families. Development of such disease models in the fly allows genetic approaches to be applied to address specific hypotheses concerning disease progression and to test candidate modifier genes. More recently these fly models have als
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