| 书目名称 | Checkpoint Controls and Targets in Cancer Therapy |
| 编辑 | Zahid H. Siddik |
| 视频video | http://file.papertrans.cn/225/224212/224212.mp4 |
| 概述 | Brings together experts, who are defining the field of checkpoints, and as such represents a unique collection of insightful contributions that will serve as an important resource for both the researc |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | .Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in signal transduction pathways that orchestrate checkpoint regulation, which may manifest through either a failure to activate the checkpoint or a failure to respond to the activated checkpoint. In normal cells, checkpoint pathways are activated when genetic or cellular homeostasis is compromised, and signals are then transduced to re-stabilize homeostasis, and, failing this, to activate the apoptotic machinery to induce a cellular suicidal response. This implies that both survival and cell death pathways are induced following checkpoint activation, and that the final decision is dependant on the net result of integrating the two sets of signals....It is intriguing that checkpoint pathways are also critical in cancer therapy to provide an apoptotic stimulus when cellular damage induced by the therapeutic agent is detected by the sensor system. Therefore, it is not surprising that failure in pro-survival checkpoint resp |
| 出版日期 | Book 2009 |
| 关键词 | BRCA; DNA; cancer; cancer research; cancer therapy; cell; cell death; leukemia; lymphoma; ovarian cancer; rese |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-60761-178-3 |
| isbn_softcover | 978-1-61779-635-7 |
| isbn_ebook | 978-1-60761-178-3Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Humana Press 2009 |
|Archiver|手机版|小黑屋|
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