Titlebook: Central Nervous System Leukemia; Prevention and Treat Renato Mastrangelo,David G. Poplack,Riccardo Ricca Book 1983 Martinus Nijhoff Publish

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The Pathology of Central Nervous System Leukemia,hese problems by examining a) the anatomy of the leptomeninges as it pertains to CNS leukemia, b) the sequence of events occurring during the histopathogenesis of meningeal leukemia, and c) the histological sequelae and their resultant clinical manifestations.

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Reduction in Central Nervous System Leukemia with a Pharmaco-kinetically derived Intrathecal-Methotosage regimen was subsequently confirmed to be less neurotoxic (2), with more consistent cerebrospinal-fluid (CSF) MTX concentrations than dosage based on body surface area (2, 3). Whether or not the altered dose schedule provided enhanced therapeutic benefit remained to be established.

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,Prophylaxis of Central Nervous System Leukaemia: British Experience, 1970–80,dence for the efficacy of such treatment (1, 2), all patients entered to subsequent trials have received some form of CNS prophylaxis. This report compares the results to date of the various prophylactic regimes used in UKALL trials I–V, to which patients were entered between 1970 and 1979.

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