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Titlebook: Central Nervous System Leukemia; Prevention and Treat Renato Mastrangelo,David G. Poplack,Riccardo Ricca Book 1983 Martinus Nijhoff Publish

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https://doi.org/10.1007/978-3-642-74678-9ely treated this disease progresses and produces characteristic anatomical sequelae and predictable clinical manifestations. This paper has reviewed these problems by examining a) the anatomy of the leptomeninges as it pertains to CNS leukemia, b) the sequence of events occurring during the histopat
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https://doi.org/10.1007/978-3-642-74697-0at cure is now a realistic goal of treatment (1). There has been increasing emphasis in recent years, therefore, on the late consequences of the disease and its therapy. These late consequences include possible organ damage, endocrine dysfunction, second malignancies, central nervous system (CNS) dy
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, Oncogenes in Chemical Carcinogenesis, that the primary volume of distribution of IT MTX approximated the extracellular-fluid volume of the central nervous system (CNS) (1). The modified dosage regimen was subsequently confirmed to be less neurotoxic (2), with more consistent cerebrospinal-fluid (CSF) MTX concentrations than dosage base
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