Titlebook: Cellular Therapies for Retinal Disease; A Strategic Approach Steven D. Schwartz,Aaron Nagiel,Robert Lanza Book 2017 Springer International

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Stem Cell-Derived RPE Transplantation: The Feasibility and Advantages of Delivery as Monolayersl-retina and choroid and provides physiological . to the overlying retina. Conditions and diseases that affect the RPE have a serious impact on normal retinal structure and function and thus on sight. The most prevalent among them, age-related macular degeneration is the leading cause of blindness i

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Induced Pluripotent Stem Cell-Derived Autologous Cell Therapy for Age-Related Macular DegenerationPE). Replacement of the atrophied RPE cell layer has previously shown potential to preserve visual acuity in autograft surgeries. However, these procedures are risky and complicated. RPE cells derived from patient-specific induced pluripotent stem (iPS) cells can be reproducibly manufactured as a ti

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Scaffolds for Cell Transplantationretinal pigmented epithelium (RPE) resulting in photoreceptor loss. Replacement of lost RPE cells with stem cell-derived RPE (SC-RPE) in patients with AMD and similar retinal diseases is currently being tested in clinical trials. Subretinal delivery of cell suspensions of SC-RPE is being investigate

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Cell Transplantation Therapy for Glaucomadegeneration of optic nerve. Like other parts of the central nervous system, retinal ganglion cells do not regenerate. Current therapies may prevent or delay further damage, but cannot restore vision. Cell transplantation therapies hold great promise for slowing disease progression and restoring vis

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Subretinal Delivery of Cells via the Suprachoroidal Space: Janssen Trialtinal space, which has traditionally been accomplished through conventional pars plana vitrectomy with the creation of a retinotomy and subsequent transfer of cells. Delivering cells in this fashion is thought to incur a risk of retinal detachment and the development of proliferative vitreoretinopat

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