Titlebook: Cellular Peptidases in Immune Functions and Diseases 2; Jürgen Langner,Siegfried Ansorge Book 2002 The Editor(s) (if applicable) and The A

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Lecture Notes in Physics Monographsinhibitors Lys[Z(NO.)]-thiazolidide and -pyrrolidide suppress the DNA synthesis of these cells in a dose-dependent manner. These data demonstrate that CD26 is also involved in the regulation of DNA synthesis of keratinocytes and that the enzymatic activity is required for mediating these effects.

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Effects of Nonapeptides Derived From the N-terminal Structure of Human Immunodeficiency Virus-1 (HIVimulated PBMC. This correlation suggests that Tat(l-9)-deduced peptides mediate antiproliferative effects at least in part via specific DP IV interactions and supports the hypothesis that CD26 plays a key role in the regulation of lymphocyte growth.

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DNA Synthesis in Cultured Human Keratinocytes and Hacat Kerationcytes is Reduced by Specific Inhibitinhibitors Lys[Z(NO.)]-thiazolidide and -pyrrolidide suppress the DNA synthesis of these cells in a dose-dependent manner. These data demonstrate that CD26 is also involved in the regulation of DNA synthesis of keratinocytes and that the enzymatic activity is required for mediating these effects.

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Unterschenkel und oberes Sprunggelenk,n addition, expression of GSK-ß an inherent component of the Wnt-pathway, was found to be increased in response to activation, but suppressed by actinonin at both the mRNA and protein level. These findings may provide a rationale for the strong growth inhibitory effects resulting from an inhibition of alanylaminopeptidase expression or activity.

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Unterschenkel und oberes Sprunggelenk,binding mechanism with inhibition constants in the nanomolare range. On the other hand, diaryl dipeptide phosphonates inhibit irreversibly. In conclusion, this work shows, that the mechanism of inhibition of DP IV depends on the structure of the investigated compounds.

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