Titlebook: Cellular Ageing and Replicative Senescence; Suresh I.S. Rattan,Leonard Hayflick Book 2016 The Editor(s) (if applicable) and The Author(s),

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Book 2016 senescence, and age-related pathologies including cancer. .Cellular Ageing and Replicative Senescence. revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. T

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Telomeres Shortening: A Mere Replicometer?ce suggests that telomeres not only limit the proliferative potential of cells, but also act as highly sensitive sensors of stress in cells. This may be a protective mechanism against cancer, but also contribute to tissue dysfunction observed during ageing.

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Small Noncoding RNAs in Senescence and Agingie restriction (CR), a reduced caloric intake without malnutrition, protects against senescence and ameliorates the age-related dysfunctions. Since sncRNAs regulate gene expression and control genome stability, it is conceivable that they may contribute to the biological and functional changes that

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Origins of the Hayflick System, the Phenomenon and the Limit

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