Titlebook: Cell and Gene Therapies; Miguel-Angel Perales,Syed A. Abutalib,Catherine Bo Book 2019 Springer Nature Switzerland AG 2019 Chimeric antigen

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Oppression and Resistance Timelinegen receptor T cells provide exciting potential for curative treatments to patients with cancers found intractable with current therapies. Toxicities are one of the main limiting factors for wide applicability of CAR-T-cell therapy. The major limiting adverse events include neurotoxicity and cytokin

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https://doi.org/10.1057/978-1-137-57664-4ll lymphocytic lymphoma (CLL/SLL) and B-cell acute lymphoblastic leukemia (B-ALL). However, targeting CD19 can result in prolonged B-cell aplasia. Given the clinical experience with the anti-CD20 monoclonal antibody rituximab with temporary B-cell aplasia, severe clinical consequence has not been ob

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Organizational Identity and Firm Growthlogy and new developments in synthetic biology have led to an ability to engineer T cells to express antibody-like recognition molecules linked to T cell-activating domains (chimeric antigen receptors, CARs) and tumor-specific T cell receptors (TCRs) which redirect patient-derived T cells toward the

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Old Age in Nineteenth-Century Irelandof the potential of immunotherapy as a therapeutic strategy. In recent years, such skepticism has diminished significantly as clinical evidence increasingly demonstrates the effectiveness of manipulating the immune system to treat a variety of established tumors. Among components of the immune syste

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https://doi.org/10.1057/978-1-137-58714-5re they continuously survey the local environment and inform cells of the immune system to modulate their responses. Under inflammatory conditions, DCs undergo terminal maturation and activation to become fully immunogenic. DC heterogeneity and differential activation states ultimately determine the

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