Titlebook: Cell and Gene Therapies; Miguel-Angel Perales,Syed A. Abutalib,Catherine Bo Book 2019 Springer Nature Switzerland AG 2019 Chimeric antigen

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Chimeric Antigen Receptor T Cells: Antigen Selection, CAR Development, and Data in Neoplastic Hematogen receptor T cells provide exciting potential for curative treatments to patients with cancers found intractable with current therapies. Toxicities are one of the main limiting factors for wide applicability of CAR-T-cell therapy. The major limiting adverse events include neurotoxicity and cytokin

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Chimeric Antigen Receptor T Cells for Leukemias in Children: Methods, Data, and Challengesacute lymphoblastic leukemia (ALL) and 50–60% with acute myeloid leukemia (AML) experience long-term disease control after multimodal treatments that often include intensified chemotherapy. Relapsed leukemia patients pose a challenging subset of the pediatric leukemic population due to highly resist

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Chimeric Antigen Receptor T Cells for Lymphomas: Methods, Data, and Challengesll lymphocytic lymphoma (CLL/SLL) and B-cell acute lymphoblastic leukemia (B-ALL). However, targeting CD19 can result in prolonged B-cell aplasia. Given the clinical experience with the anti-CD20 monoclonal antibody rituximab with temporary B-cell aplasia, severe clinical consequence has not been ob

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T Cell Receptors-Gene-Modified T Cells for Cancer: Methods, Data, and Challengeslogy and new developments in synthetic biology have led to an ability to engineer T cells to express antibody-like recognition molecules linked to T cell-activating domains (chimeric antigen receptors, CARs) and tumor-specific T cell receptors (TCRs) which redirect patient-derived T cells toward the

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Natural Killer Cells: What Have We Learned?of the potential of immunotherapy as a therapeutic strategy. In recent years, such skepticism has diminished significantly as clinical evidence increasingly demonstrates the effectiveness of manipulating the immune system to treat a variety of established tumors. Among components of the immune syste