Titlebook: Cell Division Machinery and Disease; Monica Gotta,Patrick Meraldi Book 2017 The Editor(s) (if applicable) and The Author(s), under exclusi

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Clinical Development of Anti-mitotic Drugs in Cancer, being the most successful. A deeper translational research accompanying clinical trials of anti-mitotic drugs will help in identifying potent biomarkers predictive for response. Here, we review the current knowledge of mitosis targeting agents that have been tested so far in the clinics.

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0065-2598 ese diseases. .Cell Division Machinery and Disease. is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases..978-3-319-86083-1978-3-319-57127-0Series ISSN 0065-2598 Series E-ISSN 2214-8019

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,China’s Strategy Towards East Asian Order,rrelation between aging and aneuploidy seen over the past decades. Secondly, we review the systemic impacts of aneuploidy in cell physiology and emphasize how these include some of the primary hallmarks of aging. Based on the evidence, we propose a mutual causality between aging and aneuploidy, and

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Mitotic Dysfunction Associated with Aging Hallmarks,rrelation between aging and aneuploidy seen over the past decades. Secondly, we review the systemic impacts of aneuploidy in cell physiology and emphasize how these include some of the primary hallmarks of aging. Based on the evidence, we propose a mutual causality between aging and aneuploidy, and

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Meiotic Divisions: No Place for Gender Equality,ryo. Accurate execution of the meiotic cell division to generate a female and a male gamete is required for the generation of healthy offspring harboring the correct number of chromosomes. Unfortunately, meiosis is error prone. This has severe consequences for fertility and under certain circumstanc

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Consequences of Centrosome Dysfunction During Brain Development,f cell division, the extent of proliferation and the spatial distribution of mitosis allow the formation of tissues of the right size and with the correct structural organization. All these aspects depend on cell cycle duration, correct chromosome segregation and spindle orientation. The centrosome,

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Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells,standers in cancer but can accelerate tumourigenesis in the absence of the tumour suppressor p53. Centrosome amplification could indeed actively participate in tumour progression through the induction of chromosome instability, disruption of tissue architecture and promoting cell invasion. Paradoxic

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Kinetochore Malfunction in Human Pathologies,s on correct connections between chromosomes and spindle microtubules. Kinetochores are complex multi-protein assemblies that mediate these connections and are the platforms for attachment-error-correction and spindle assembly checkpoint signaling. Proper kinetochore function is therefore key in pre