Titlebook: Cell Death Signaling in Cancer Biology and Treatment; Daniel E. Johnson Book 2013 Springer Science+Business Media New York 2013 Cancer.Can

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Harnessing Death Receptor Signaling for Cancer Treatment,gulation of the signaling events and their perturbation in human cancers may lead to the identification of new molecular targets that can be exploited for therapeutic purposes. This strategy is expected to open new perspectives to target the death receptor pathway for cancer therapy.

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New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathwaymotherapeutic drug resistance. This chapter will first briefly describe these pathways and then evaluate potential uses of Raf, MEK, PI3K, Akt, and mTOR inhibitors that have been investigated in preclinical and clinical investigations.

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Wax Control and Removal in Oil Wellopment and application of three small molecule inhibitors (ABT-737, ABT-263, GX15-070), with a particular emphasis on progress that has been made in the evaluation of these compounds in preclinical in vivo models and clinical trials.

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Ventilation in Office Buildingss for selective growth inhibition or death by targeting non-redundant pathways in cancer cells. These “metabolic dependencies” are not likely to be associated with classically defined oncogenes or computationally derived drivers and thus may require novel strategies for discovery.

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https://doi.org/10.1007/978-981-13-2925-8olipids, are believed to play anti-apoptotic roles and offer drug resistance to currently used chemotherapeutic drugs. These emerging biologic roles of sphingolipids and its potential usefulness in treating cancer in the form of anticancer therapeutics are discussed in this chapter.

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Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment,olipids, are believed to play anti-apoptotic roles and offer drug resistance to currently used chemotherapeutic drugs. These emerging biologic roles of sphingolipids and its potential usefulness in treating cancer in the form of anticancer therapeutics are discussed in this chapter.