| 书目名称 | Cell Death | | 副标题 | Mechanism and Diseas | | 编辑 | Hao Wu | | 视频video | | | 概述 | Provides a comprehensive view of cell death.Details the role of cell death in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response.Discusses the potential promise of targ | | 图书封面 |  | | 描述 | .Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy..Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response. When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key player | | 出版日期 | Book 2014 | | 关键词 | Apoptosis; Cell death; Receptors | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4614-9302-0 | | isbn_softcover | 978-1-4939-4325-8 | | isbn_ebook | 978-1-4614-9302-0 | | copyright | Springer Science+Business Media New York 2014 |
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发表于 2025-3-21 17:32:11
