Titlebook: Cell Cycle Inhibitors in Cancer Therapy; Current Strategies Antonio Giordano,Kenneth J. Soprano Book 2003 Springer Science+Business Media N

Ventricle

Lucinda Backwell,Francesco d’Erricouppressor genes may result in an unregulated cell cycle and eventual neoplastic transformation (Table 1). As such, one might define cancer as a genetic disease of the cell cycle. An understanding of the regulatory control of the cell cycle will be needed to understand some of the most common genetic abnormalities of tumors.

神刊

Tumor-Suppressor Genes as Diagnostic Tools,uppressor genes may result in an unregulated cell cycle and eventual neoplastic transformation (Table 1). As such, one might define cancer as a genetic disease of the cell cycle. An understanding of the regulatory control of the cell cycle will be needed to understand some of the most common genetic abnormalities of tumors.

分开如此和谐

Lucinda Backwell,Francesco d’Erricoignals that operate within distinct biological contexts. Equally important from a clinical perspective, fidelity of cell cycle regulatory mechanisms is compromised in transformed and tumor cells and in nonmalignant disorders, and reflects deregulation of cell growth or abrogation of cell death.

镶嵌细工

Science in Transition Reduced to Practice, DNA duplication, preventing the propagation of these errors to daughter cells. In contrast, the G. phase represents the period of commitment to cell cycle progression that separates M and S phases as cells prepare for DNA duplication upon mitogenic signals ..

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mydriatic

Maria Teresa Riviello,Anna Espositoplicates its genome, and M phase, in which the cell splits into two daughter cells. It is necessary that these two crucial events are regulated and coordinated to occur in an ordered fashion at precisely the right time (for a review . refs. .). This regulation and coordination results from a combina

动机

Maria Teresa Riviello,Anna Esposito survival of patients with tumors of the colon, breast, prostate, lung, pituitary, and many other tissues. Tumors arising in these organs that were not expressing p27 protein tended to be more aggressive and patients had a poorer clinical outcome. However, it is not clear why p27 was such a strong p

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一致性