Titlebook: Cell Culture in Pharmaceutical Research; N. E. Fusenig,H. Graf Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Pharmace

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https://doi.org/10.1007/978-94-015-7568-3tems for developmental biologists. ES cells offer a suitable model to study in vitro cell differentiation and development of the mammalian organisms. Recent applications include gene targeting strategies (Thomas and Capecchi 1987) and the investigation of developmentally regulated genes using promot

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,Die Entwicklung des Dünenindividuum,stocysts) and are maintained in culture for long periods of time, during which they can be genetically manipulated and selected. The most intriguing property of these cells is that following in vitro culture they can still participate in the development of mice in vivo, when returned to the early em