Titlebook: Cell Culture in Pharmaceutical Research; N. E. Fusenig,H. Graf Conference proceedings 1994 Springer-Verlag Berlin Heidelberg 1994 Pharmace

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0947-6075 on to animal experiments we are now able to better define the overall and the selective potential of drugs. This book is designed to give information on the advantages and limitations and on new aspects and the meaning of cell culture models in pharmaceutical research.978-3-662-03013-4978-3-662-03011-0Series ISSN 0947-6075

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Orthogonal and Symplectic Geometries,r hand, it is well established that unaltered amplitude and frequency of pulsatile GnRH secretion allows full steroidal control of gonadotropin secretion, indicating the importance of the pituitary level in feedback regulation (Knobil 1980; O’Byrne et al. 1991).

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Applications of Expression Vectors Containing Bicistronic Transcription Units in Mammalian Cells,terodimers has been succesfully carried out in mammalian cell lines. However, unequal expression of the relevant genes is disadvantageous for subunit assembly and possibly influences the secretion process. A prerequisite for this process is the stoichiometric expression of the transferred genes.

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Cell Culture Models: Reliable Tools in Pharmacotoxicology?, systems are directly applicable to the in vivo situation. It must be admitted that the understanding of the special biological situation of the isolated cells in culture, the “in vitro physiology,” is often not considered sufficiently either in the application of existing in vitro systems or in the

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Tight Junctions and the Blood-Brain Barrier,d of recovery from the initial insult. The barrier is also abrogated, albeit transiently, when cells enter the brain from the blood. This happens in disorders such as multiple sclerosis, caused, presumably, by the entry of activated oligodendrocyte-reactive T-lymphocytes into the brain. Cell traffic

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The Use of Animal Tumor Models to Study the Role of the Tumor Microenvironment and Paracrine and Aur or the configuration of the lymphatics or circulatory system. It is now well known that mechanical and anatomical considerations, such as mechanical lodgement of tumor cell emboli in the first capillary bed encountered, are important factors in lymphatic tumor spread, but many cancers that spread