| 书目名称 | Cell Culture Engineering | | 编辑 | Wei-Shou Hu | | 视频video | http://file.papertrans.cn/223/222768/222768.mp4 | | 概述 | Covers trends in modern biotechnology.All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemic | | 丛书名称 | Advances in Biochemical Engineering/Biotechnology | | 图书封面 |  | | 描述 | Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadeni | | 出版日期 | Book 2006 | | 关键词 | Biotechnology; Cell Culture; Escherichia coli; biochemical engineering; cell biology; post-translational | | 版次 | 1 | | doi | https://doi.org/10.1007/11751571 | | isbn_softcover | 978-3-642-07051-8 | | isbn_ebook | 978-3-540-34007-2Series ISSN 0724-6145 Series E-ISSN 1616-8542 | | issn_series | 0724-6145 | | copyright | Springer-Verlag Berlin Heidelberg 2006 |
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