Titlebook: Cardiovascular Pharmacology of 5-Hydroxytryptamine; Prospective Therapeu P. R. Saxena,D. I. Wallis,P. Bevan Book 1990 Springer Science+Busi

Congruous

Dirichlet Series and ,-Functionsthe pineal gland and the platelets contain important concentrations of 5-HT. The indoleamine has also been detected in peripheral nerves of the gut, in lung, kidney, spleen, thyroid, mast cells, heart and blood vessels of different species. It is well accepted that 5-HT has a role as a neurotransmit

减震

别炫耀

Diophantine Aspects of Elliptic Curves homologies among one group of receptors, the G protein-coupled receptors, that unite these proteins into one structural family [1]. Members of this family include the muscarinic cholinoceptors, alpha- and beta-adrenoceptors, opsin and the Substance K receptor [1, 2]. All members of this family are

Magnificent

Diophantine Aspects of Elliptic Curves receptors, leading to the identification of membrane-bound specific sites with pharmacological properties expected for such receptors. Three main classes of 5-HT binding sites designated 5-HT.,5-HT. and 5-HT. have been identified so far [1], Apparently a single homogeneous population of sites corre

SPER

DENT

Omniscient

预感

Abelian Groups, Lattices, and Finite Fieldsecently shown to be negatively coupled to adenylyl cyclase in the calf substantia nigra [6]. Yet additional 5-HT receptors exist, not only in mammalian smooth muscles and other peripheral tissues [1, 3] but in brain as well. For example, the hippocampus has binding sites (and probably the homologous

Affectation

https://doi.org/10.1007/978-0-387-49923-9 the effects of 5-hydroxytryptamine (5-HT), causing a simple rightward shift of the concentration-effect curve for 5-HT. Other antagonists cause a rightward shift of the concentration-effect curve and a depression of maximum responses to 5-HT which cannot be surmounted by increased concentrations of

施加

Introduction to Diophantine Equationsmited to a single mechanism, and therefore its utility for receptor identification, characterization, and classification is at best limited. In general, however, the mechanistic bases of unsurmountable antagonism have not received rigorous attention. The objectives of this chapter are to document in