Titlebook: Cardiovascular Drug Therapy; Nitrate Therapy Adam Schneeweiss Book 1990 Springer-Verlag Berlin Heidelberg 1990 Angina pectoris.Heart failur

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,Origins of Symptoms in Heart Failure — Relevance in Evaluation of New Drugs,Evaluation of symptoms in heart failure is now possible with greater accuracy, using quality of life questionnaires. The topic was reviewed by Poole-Wilson.

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Mononitrates,The term “mononitrates” refers in general to the two metabolites of ISDN, namely, IS-5-MN and IS-2-MN. These metabolites are formed in the liver.

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Are There Differences Between the Various Formulations of Nitrates in Heart Failure?,tes of administration which should be known in order to optimize nitrate therapy. This discussion does not relate to obvious differences such as between transdermal nitroglycerin patches and sublingual nitroglycerin tablets but to more delicate differences. Three examples will be mentioned:

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,Long-Term Nitrate Therapy — A Decade of Changing Concepts,d with certainty. With the intention of confirming their effectiveness, Rudolph and his coworkers began performing controlled studies in 1978, the results of which, however, were suggestive of a development of tolerance and rendered questionable the indication for chronic use of nitrates in the trea

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Nitrate Therapy in Angina Pectoris,erance. Although this theory is in contrast to the clinical experience of most cardiologists, it is supported by evidence from controlled trials, reported by Parker, Rudolph, Thadani and their coworkers. In this chapter the subject is reviewed, with the conclusion that tolerance to the antianginal e

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