Titlebook: Cardiovascular Applications of Stem Cells; Khawaja H. Haider Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive li

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Cardiac Reprogramming with Stem Cells: An Advanced Therapeutic Strategy in Advanced Heart Failure,with ischemia and non-ischemia severe HF have shown conflicting survival results after implantation of bone marrow mesenchymal stem cells and human induced pluripotent stem cells. Still, cardiac function was substantially improved in the majority of the investigations. It has been disputed that impr

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,“Heart Cells” Derived from Pluripotent Stem Cells and Therapeutic Applications,iomyocytes, cardiac progenitor cells, cardiac fibroblasts, and endothelial cells derived from genetically and conditionally reprogrammed induced pluripotent stem cell (iPSC) sources using well-defined differentiation protocols has emerged. While these “heart cells” are well characterized and can be

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Cardiac Progenitor Cells in Cardiac Tissue Repair,e shown improved cardiac function, attenuation of infarction scar, reduction in myocyte apoptosis, prevention of LV remodeling, and increased myocardial perfusion. Likewise, clinical trials like the SCIPIO, CONCERT-HF, CADUCEUS, ALCADIA, ALLSTAR, DYNAMIC, and CAREMI have demonstrated improvements in

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Stem Cell Applications in Cardiac Tissue Regeneration,ryonic stem cells and induced pluripotent stem cells (IPSCs). This chapter reviews the different strategies to differentiate stem/progenitor cells by preconditioning or induction using bioactive factors (transcription factors, growth factors, microRNAs, small molecule compounds, and scaffolds). We e

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Human Myoblast Genome Therapy and the Regenerative Heart,ocardium, and 6-min walk distance (6MWT) by 90 m. Allogeneic myoblast transplantation (AMT) following CABG and cyclosporine immunosuppression prolonged the life spans for 2 years on ten end-stage heart failure (HF) patients with 2.21 ± 0.55 mm mean thinnest wall thickness and scary ventricular aneur

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The Effect of Time of Cell Delivery on Post-MI Cardiac Regeneration: A Review of Preclinical and Clue to the lack of standardization of cell isolation and delivery methods, these trials showed controversial results regarding effectiveness. Several issues concern the translation of the experimental data into the clinic, discussing the adequate cell type, dosing, timing, and delivery mode of myocar