Titlebook: Cardiovascular Applications of Stem Cells; Khawaja H. Haider Book 2023 The Editor(s) (if applicable) and The Author(s), under exclusive li

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Therapeutic Targeting of Epicardial and Cardiac Progenitors in the Heart Regeneration,paracrine activity. These cellular and molecular events are necessary for restoring and repairing the adult heart during injury. The mechanistic involvement of the epicardium remains a vital component of intrinsic cardiac repair. Moreover, the growth of neovasculature can be initiated by activating

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Human Myoblast Genome Therapy and the Regenerative Heart,ologous and allogeneic myoblast implants were shown to have . in infarcted myocardia of end-stage heart patients and . into (1) skeletal myofibers, (2) cardiomyocytes, and (3) heterokaryotic myofibers that jointly . in contractile augmentation. Two weeks’ rather than life-long immunosuppression was

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Avant-Garde Hydrogels as Stem Cell Niche for Cardiovascular Regenerative Medicine,ple lose their lives each year due to cardiac dysfunction. Nearly 75% of the cases are related to heart attack, stroke, and heart failure. Furthermore, the limited restoration capacity of the adult cardiac tissue leads to irreversible changes in myocardial injury and ischemia, which seriously increa

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Human Stem Cell-Derived Cardiac Organoid-Like Structures: Generation and Applications,mposition that mimic cardiac tissue structure and complexity. Stem cells, particularly pluripotent stem cells, fundamentally contributed to creating cardiac organoids. Indeed, the differentiation of stem cells into various cardiac cells, including cardiomyocytes, endothelial cells, cardiac fibroblas

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Stem Cells in Heart Failure: Future Perspective,iated with either functional or structural impairment of ventricles impacting left ventricle mechanics with systolic and/or diastolic dysfunction. Respectively, there are two main HF phenotypes, namely, heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fr

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Storage and Disposal of Nuclear Wastes,rocess will offer a novel option for the treatment of the injured heart. We aim to discuss the significance of epicardial and cardiac stem/progenitors, key molecular pathways in their activation and epicardial secretome, sub-epicardial niche, and therapeutic targeting of epicardium for cardiac recovery.

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Induced Pluripotent Stem Cells and Allogeneic Mesenchymal Stem Cell Therapy in Cardiovascular Diseaechanical assessment of the myocardial viability delineating target zones for cells or gene constructs delivery. This chapter will also focus on clinical aspects and current strategies for ATMPs therapies in recent and prospective clinical trials.