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Titlebook: Cardiac Glycosides 1785–1985; Biochemistry — Pharm Erland Erdmann,K. Greef,J. C. Skou Conference proceedings 1986 Springer-Verlag Berlin He

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The human red blood cell: A model for ouabain receptor regulation in the heart?sults were obtained:.The differences in ouabain receptor regulation in erythrocytes and heart muscle cells may be attributable to the lack of a “sodium pump reserve” in erythrocytes. Such variations in receptor regulation indicate that the human erythrocyte is not a suitable model for the ouabain receptor in the human heart.
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Jiři Outrata,Michal Kočvara,Jochem Zowesults were obtained:.The differences in ouabain receptor regulation in erythrocytes and heart muscle cells may be attributable to the lack of a “sodium pump reserve” in erythrocytes. Such variations in receptor regulation indicate that the human erythrocyte is not a suitable model for the ouabain receptor in the human heart.
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William Withering — The man and his workopsy and other Diseases” (6). This is a critical analysis of the effect of digitalis on dropsy based on ten years of observations with reports of 163 cases treated by Withering, and a number of cases treated by colleagues. Detailed instructions are given on how to use digitalis, on the dosage, on th
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Fruitful routes and blind alleys taken by digitalis therapy since its introduction by Witheringress the subject of digitalis therapy and all its problems. Not only was he a prominent expert in this field, but he had also studied the history of digitalis in the last years of his life. Unfortunately he died in 1981. Therefore, Professor Kurt Greeff (born 1920) and I published some time ago a sh
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The function of Na+,K+-ATPase and its importance for drug actionlar Ca. concentration is markedly affected by the balance between Na.,K.-ATPase activity (capacity of the sodium pump) and Na. influx rate. The sodium pump in cardiac muscle has a substantial reserve capacity under normal conditions; however, a relatively modest sodium pump inhibition or an increase
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Interaction of cardiac glycosides with Na/K-ATPase in intact myocardiumhe interaction of cardiac glycosides with Na/K-ATPase of intact myocardium were quantitatively considered and combined: 1. Cardiac glycoside binding depends on the turnover rate of Na/K-ATPase, and 2. occupation and inhibition of a fraction of Na/K-ATPases by cardiac glycoside leads to an increased
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