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Titlebook: Cardiac Cell and Gene Transfer; Joseph M. Metzger (Director) Book 2003 Humana Press 2003

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https://doi.org/10.1007/978-3-319-67140-6myocardial infarction (.–.). Our long term goals are to induce muscular regeneration of the infarcted region. This chapter focuses on our work using skeletal muscle cell transplantation for cardiac regeneration.
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Gutted Adenoviral Vectors for Gene Transfer to Musclegutted” or helper-dependent adenoviruses, which lack all viral coding sequences and therefore should greatly enhance the persistence of the vector in vivo (.,.). We have used this technology to deliver to muscle full-length cDNAs of the largest known gene, dystrophin, under control of the mouse muscle creatine kinase enhancer plus promoter (.–.).
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https://doi.org/10.1007/978-3-319-30357-4gutted” or helper-dependent adenoviruses, which lack all viral coding sequences and therefore should greatly enhance the persistence of the vector in vivo (.,.). We have used this technology to deliver to muscle full-length cDNAs of the largest known gene, dystrophin, under control of the mouse muscle creatine kinase enhancer plus promoter (.–.).
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Dennis J. W. Belleter,Kristin Y. Pettersenuch as naked or liposome-complexed DNA. At the same time, rAAV also displays the least inflammatory response in comparison with other viral vectors such as adenovirus and herpes simplex virus (.). Regulated myocardial transgene expression has also been demonstrated with an AAV vector containing glucocorticoid response elements in rat heart (.).
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https://doi.org/10.1007/978-1-4757-3108-8very. This review details techniques for the purification of commonly investigated cell grafts, including skeletal myoblasts and mesenchymal stem cells, and the methods to deliver these grafts to the myocardium of laboratory animals.
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