Titlebook: Carbohydrates as Drugs; Peter H. Seeberger,Christoph Rademacher Book 2014 Springer International Publishing Switzerland 2014 Anti-Influenz

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Multi-Objective Branch and Boundcellular targets, and (2) the lectins are targets of the so-called anti-virulence therapy and therefore a reduced appearance of resistances towards lectin-directed drugs can be anticipated. In this review, the recent development of carbohydrate-based inhibitors against both lectins is summarized with a main focus on small molecules.

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Carbohydrate-Based Anti-Virulence Compounds Against Chronic , Infections with a Focus on Small Molecellular targets, and (2) the lectins are targets of the so-called anti-virulence therapy and therefore a reduced appearance of resistances towards lectin-directed drugs can be anticipated. In this review, the recent development of carbohydrate-based inhibitors against both lectins is summarized with a main focus on small molecules.

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Book 2014. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-wor

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Computational Docking as a Tool for the Rational Design of Carbohydrate-Based Drugs,so significant limitations and care needs to be taken when evaluating the docking results. In this chapter the challenges, limitations, and possible pitfalls in docking of carbohydrates are described. Practical examples explain the use of docking methods for the rational design of carbohydrate-based

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Discovery and Development of Selective Renal Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Dapaged primarily by the sodium-dependent glucose transporter 2 (SGLT2) as the glomerular filtrate flows down the renal tubules. SGLT2 inhibitors inhibit this transporter leading to the loss of a significant fraction of the filtered glucose. The resulting glucosuria is of sufficient magnitude to reduce d

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