Titlebook: Carbohydrates as Drugs; Peter H. Seeberger,Christoph Rademacher Book 2014 Springer International Publishing Switzerland 2014 Anti-Influenz

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Carbohydrates as Drugs978-3-319-08675-0Series ISSN 1862-2461 Series E-ISSN 1862-247X

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Book 2014roughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known

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Obtention of Auxotrophic Mutants in ,d selective .SGLT2 inhibitor with an EC. for .SGLT2 of 1.0 nM and 1,200-fold selectivity over .SGLT1. Dapagliflozin produced glucosuria in normal Sprague Dawley rats in a dose-dependent fashion. Moreover, a 0.1 mg/kg oral dose reduced blood glucose levels by as much as 55% in rats that had been made

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Martin Ramirez-Orozco,Jose Luis Ochoa been important in elucidating galectin-3 mechanisms, including galectin-3 trafficking, cancer, inflammation, fibrosis, and angiogenesis. Medically relevant models using the galectin-3 modulators in characterizing macrophage alternative activation and chronic inflammation, myofibroblast activation a

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Klaus Wolf,Karin Breunig,Gerold Barthdhesion can be attributed to structural differences in the mannosidic receptors than based on amino acid variance in FimH. The crystal structure of FimH in complex with oligomannoside-3 presented a breakthrough that enhanced the rational design of mannose-based anti-adhesives against FimH. In this o

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Statistical Models Based Algorithmsake and processing of the antigen and resulted in a five-fold higher mannan-specific antibody response together with a cytokine profile appropriate for an antifungal vaccine. When the same trisaccharide was conjugated to a T-cell peptide derived from . cell-wall protein, the resulting glycopeptide–t

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