Titlebook: Capturing Chromosome Conformation; Methods and Protocol Beatrice Bodega,Chiara Lanzuolo Book 2021 Springer Science+Business Media, LLC, par

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https://doi.org/10.5822/978-1-59726-377-1tched linear molecule. After that, a huge advance in the knowledge of the structure of the eukaryotic genome in the nuclear space has been made over the last decades, bringing us to the widely accepted concept that the genome is packaged into hierarchical levels of higher-order three-dimensional str

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https://doi.org/10.1007/978-3-319-21680-5croscopic methods. Among the method derivatives, 4C-seq (circular chromosome conformation capture, coupled to high-throughput sequencing) is a versatile, cost-effective means of assessing all chromatin interactions with a specific genomic region of interest, making it particularly suitable for inter

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Space Geometry from Ancient Greece to Today in topologically associating domains (TADs), and site-specific looping interactions. The discovery of this genome hierarchical organization emerged from the computational analysis of chromatin capture data. With the increasing availability of such data, automatic pipelines for the robust comparison

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Space Geometry from Ancient Greece to Todaylar approaches has unraveled the existence of DNA territories. With the emergence of affordable deep-sequencing approaches, “Cs” techniques such as 4C, 5C, and HiC, to name a few, are now routinely performed by the scientific community in a large number of model systems. We have modified the HiC app

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,Pilze, Lebenspartner der Waldbäume,t diverse scale lengths with chromosomes occupying distinct volumes and individual chromosomes folding into compartments, inside which the chromatin fiber is packed in large domains (as the topologically associating domains, TADs) and forms short-range interactions (as enhancer-promoter loops). The

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,Pilze, Lebenspartner der Waldbäume,d is often used alongside chromosome conformation capture approaches to obtain a better-rounded view of the functional relationship between chromatin architecture and its landscape. Since the inception of ChIP, its protocol has been modified to improve speed, sensitivity, and specificity. Combining

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