Titlebook: Cancer: Cell Structures, Carcinogens and Genomic Instability; Leon P. Bignold Book 2006 Birkhäuser Basel 2006 angiogenesis.animals.apoptos

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Cancer morphology, carcinogenesis and genetic instability: a background,s and chromosomes in tumour cells were described in the late 1880s. Von Hansemann, in the 1890s, suggested that tumour cells develop from normal cells because of a tendency to mal-distribution and other changes of chromosomes occurring during mitosis. In the first decades of the 20th century, Mendel

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协议

Aneuploidy, stem cells and cancer,ivisions play an important role in cellular aging. Aging and cancer development are linked with each other because cancer is considered a group of complex genetic diseases that develop in old cells and, in both, telomere attrition is involved. Numeric chromosome imbalance also known as aneuploidy is

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The mode of action of organic carcinogens on cellular structures,w organic carcinogens are bioactivated into DNA-reactive descendants. Beginning with the history of discovery of some important human organic carcinogens, the text guides through the development of the knowledge on their molecular mode of action that has grown over the past decades. Some of the most

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Metal ions and carcinogenesis,ites of critical protein function, such as zinc finger motifs and electron or oxygen carriers. These functions only require essential metals in minute amounts, hence they are termed trace metals. Other metals are, however, less beneficial, owing to their ability to promote a wide variety of deleteri

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Chipmunk

Viral carcinogenesis and genomic instability, regulatory circuits that regulate cellular proliferation, differentiation, apoptosis and life span. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Some viral oncoproteins act as powerful mutator genes and the

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MELON

Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications,n the remodeling of various organ systems, and in several pathologies, particularly cancer. In the last 20 years of angiogenesis research, a variety of angiogenic regulators, both positive and negative, have been identified. The discovery of several anti-angiogenic factors has led to the development