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Titlebook: Cancer: Cell Structures, Carcinogens and Genomic Instability; Leon P. Bignold Book 2006 Birkhäuser Basel 2006 angiogenesis.animals.apoptos

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Actions of ultraviolet light on cellular structures,tion processes to yield free radicals (Type I); or (b) energy transfer with O2 to yield the reactive excited state, singlet oxygen (Type II). Direct UV absorption by DNA leads to dimers of nucleic acid bases including cyclobutane pyrimidine species and pyrimidine (6–4) pyrimidone compounds, together
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,Actions of radiation on living cells in the “post-bystander” era,posure. In this chapter we review the history of radiation biology which led to the DNA paradigm. We explore the issues and the evidence which are now challenging the view that dose deposition in DNA is all important. We conclude that in the low-dose region, the primary determinant of radiation expo
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https://doi.org/10.1007/978-3-211-78891-2 methylation and histone modifications are two epigenetic mechanisms that are altered in cancer cells. The impact of genetic (e.g., mutations in Rb and ras family) and epigenetic alterations with a focus on histone modifications on chromatin structure and function in cancer cells are reviewed here.
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