Titlebook: Cancer and Zebrafish; Mechanisms, Techniqu David M. Langenau Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive lic

啮齿动物

Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Modelival and migration can be tested by simply adding the compound into the water of living embryos. Therefore the zebrafish model offers the opportunity to gain more knowledge on cancer angiogenesis and metastasis in vivo with the final aim of providing new translational insights into therapeutic appro

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The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Toolmary patient material by virtue of the relatively low number of cells required for each embryo (between 50 and 300 cells), the absence of an adaptive immune system in the early zebrafish embryo, and the short experimental timeframe (5–7 days). Following xenotransplantation into the fish, cells can b

CRUDE

Automation of Technology for Cancer Researchling and sorting, microfluidic systems for imaging and drug treatment, and image acquisition and analysis. Examples will be given of employment of these technologies within the fields of toxicology research and cancer research.

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Selected Applications of Geostatical Methodspressors at the spatial and temporal level. Methods such as the Gal4/UAS or the Cre/lox systems paved the way to the development of elegant tumor models, which are now being used to study cancer cell biology, clonal evolution, identification of cancer stem cells and anti-cancer drug screening. Combi

FLAT

Selected Applications of Geostatical Methods. Zebrafish is a powerful model for studying tumorigenesis and has been successfully exploited in drug discovery. According to the zebrafish reference genome, 82 % of disease-associated genes in the Online Mendelian Inheritance in Man (OMIM) database have clear zebrafish orthologues. Using a variety

使长胖

Introducing Geostatistical Methods and tumors develop late in life. Functional inactivation of tumor suppressors is a crucial step in cancer progression and more and more tumor suppressor genes are being studied in zebrafish. Most often tumor suppressors have been inactivated by reverse genetics approaches using targeted disruption.